3-CHLORO-N-METHYLANILINE synthesis
- Product Name:3-CHLORO-N-METHYLANILINE
- CAS Number:7006-52-2
- Molecular formula:C7H8ClN
- Molecular Weight:141.6
Yield: 96%
Reaction Conditions:
with C19H37IrN4(2+)*2I(1-);potassium carbonate at 120; for 17 h;Inert atmosphere;Schlenk technique;Sealed tube;
Steps:
N-Monomethylation of a Variety of Aromatic Amines with Methanol Catalyzed by 4c Shown in Scheme 1; General Procedure
General procedure: In a stainless reactor bomb, the respective aromatic amine (1.0mmol), 4c (0.50 mol%), K2CO3 (5.0 mol%), and MeOH (1.0 mL) were placed. Then, the reactor was sealed with a stainless stopper, and the mixture was stirred for 17 h at 120 °C. After removing MeOH under reduced pressure, the products were isolated by silica gel column chromatography.
References:
Toyooka, Genki;Tuji, Akiko;Fujita, Ken-Ichi [Synthesis,2018,vol. 50,# 23,p. 4617 - 4626]
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