3-(ChloroMethyl)pyridazine hydrochloride synthesis
- Product Name:3-(ChloroMethyl)pyridazine hydrochloride
- CAS Number:27349-66-2
- Molecular formula:C5H6Cl2N2
- Molecular Weight:165.02
1632-76-4
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87-90-1
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$10.00/10g
27349-66-2
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$45.00/10mg
Yield:27349-66-2 80%
Reaction Conditions:
in chloroform;Reflux;
Steps:
Intermediate 2: 3-(Chloromethyl)pyridazine hydrochloride.
Method B: 3-(Chloromethyl)pyridazine. Trichloroisocyanuric acid (148 mg, 0.6 mmol) was added in portions to a mixture of 3-methylpyridazine (145 μL, 1.6 mmol) in CHCl3 at reflux. The mixture was stirred at reflux overnight. After cooling, the mixture was filtered, and the filtrate was diluted with DCM, washed with an aqueous solution of 1M NaOH followed by brine, dried (MgSO4) and concentrated under reduced pressure to yield title compound (205 mg, 80%). MS (ESI): mass calcd. for C5H5ClN2, 128.0; m/z found, 129 [M+H]+. Intermediate 3: 5-(Chloromethyl)pyrimidine hydrochloride.
References:
WO2018/67786,2018,A1 Location in patent:Page/Page column 103; 104
37444-46-5
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27349-66-2
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$45.00/10mg
98-00-0
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27349-66-2
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19969-71-2
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$75.00/500mg
27349-66-2
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$45.00/10mg