![](/CAS/GIF/37444-46-5.gif)
Pyridazin-3-ylmethanol synthesis
- Product Name:Pyridazin-3-ylmethanol
- CAS Number:37444-46-5
- Molecular formula:C5H6N2O
- Molecular Weight:110.11
![Pyridazine-3-carboxylic acid ethyl ester](/CAS/GIF/1126-10-9.gif)
1126-10-9
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![Pyridazin-3-ylmethanol](/CAS/GIF/37444-46-5.gif)
37444-46-5
129 suppliers
$18.00/100mg
Yield: 26%
Reaction Conditions:
with lithium aluminium tetrahydride in tetrahydrofuran at 0; for 0.5 h;
Steps:
71.2 Step 2: pyridazin-3-ylmethanol
To a solution of ethyl pyridazine-3-carboxylate (0.641 g, 4.21 mmol) in THF (20 mL) at 0 °C was added a solution of lithium aluminum hydride in tetrahydrofuran (1.0 M, 4.21 mL, 4.21 mmol) dropwise. The resulting suspension was stirred for 30 min. Solid Na2S04 *10 H20 was added and the mixture was diluted with EtOAc and stirred for lh. The mixture was filtered through a pad of celite and the residual solid was washed with EtOAc several times. The filtrate was concentrated under reduced pressure. The crude product was purified by silica gel chromatography to afford the product as brown solid (120 mg, 26%). LCMS (AA): m/z 111 (M+H).
References:
MILLENNIUM PHARMACEUTICALS, INC.;ADHIKARI, Sharmila;CALDERWOOD, Emily, Frances;ENGLAND, Dylan, Bradley;GOULD, Alexandra, E.;HARRISON, Sean, J.;HUANG, Shih-Chung;MA, Liting WO2018/89786, 2018, A1 Location in patent:Paragraph 00398
![2,5-Dihydro-2,5-dimethoxyfurfuryl alcohol](/CAS/GIF/19969-71-2.gif)
19969-71-2
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$75.00/500 mg
![Pyridazin-3-ylmethanol](/CAS/GIF/37444-46-5.gif)
37444-46-5
129 suppliers
$18.00/100mg
![Furfuryl alcohol](/CAS/GIF/98-00-0.gif)
98-00-0
457 suppliers
$23.00/25mL
![Pyridazin-3-ylmethanol](/CAS/GIF/37444-46-5.gif)
37444-46-5
129 suppliers
$18.00/100mg
![3-Pyridazinecarboxylic acid](/CAS/GIF/2164-61-6.gif)
2164-61-6
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$19.00/250mg
![Pyridazin-3-ylmethanol](/CAS/GIF/37444-46-5.gif)
37444-46-5
129 suppliers
$18.00/100mg
![2,5-dimethoxy-2,5-dihydrofuran-2-yl)methyl acetate](/CAS/20180808/GIF/41991-02-0.gif)
41991-02-0
4 suppliers
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![Pyridazin-3-ylmethanol](/CAS/GIF/37444-46-5.gif)
37444-46-5
129 suppliers
$18.00/100mg