3-Cyano-2-fluorophenol synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane; dimethyl sulfoxide / 3 h / 105 °C / Inert atmosphere
2: acetic acid; dihydrogen peroxide / water / 2 h / 20 °C / Inert atmosphere

References:

CTXT PTY LIMITED;STUPPLE, Paul, Anthony;LAGIAKOS, Helen, Rachel;MORROW, Benjamin, Joseph;FOITZIK, Richard, Charles;HEMLEY, Catherine, Fae;CAMERINO, Michelle, Ang;BOZIKIS, Ylva, Elisabet, Bergman;WALKER, Scott, Raymond WO2019/243491, 2019, A1

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