(3-cyanophenyl) acetate synthesis
- Product Name:(3-cyanophenyl) acetate
- CAS Number:55682-11-6
- Molecular formula:C9H7NO2
- Molecular Weight:161.16
873-62-1
265 suppliers
$6.00/1g
55682-11-6
7 suppliers
$10.60/250mg
Yield:-
Reaction Conditions:
at 20; for 2 - 18 h;
Steps:
5
To a phenol, was added an acetylation reagent, such as acetyl chloride (1.0-2.0) or acetic anhydride, and the reaction mixture stirred for 2-18 hours at a temperature between room temperature and reflux. Excess acetylation reagent was removed in vacuo, then the O-acetylated phenol was treated with AICI3 (1.0-1.25 eq) and heated to a high temperature, such as 180° C for 30-60 minutes. The reaction mixture was then cooled, quenched with aqueous acid, and filtered to afford the desired ortho- ' hydroxyacetophenone.Hydroxyacetophenones were prepared, using the method of Hydroxyacetophenone Preparation 5, from commercially available reagents as follows: 4-Acetyl-3-hydroxy-benzonitrile from 3- hydroxybenzonitrile, 1-(5-chloro-4-fluoro-2-hydroxyphenyl)ethanone from 4-chloro-3-fluorophenol,
References:
PFIZER PRODUCTS INC. WO2008/65508, 2008, A1 Location in patent:Page/Page column 25-26
122-46-3
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$21.00/1g
55682-11-6
7 suppliers
$10.60/250mg
873-62-1
265 suppliers
$6.00/1g
108-24-7
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$14.00/250ML
55682-11-6
7 suppliers
$10.60/250mg
873-62-1
265 suppliers
$6.00/1g
830-03-5
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$10.00/5g
100-02-7
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$11.00/5G
55682-11-6
7 suppliers
$10.60/250mg
22241-18-5
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$110.00/50mg
108-24-7
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$14.00/250ML
55682-11-6
7 suppliers
$10.60/250mg