3-cyclopropyl-4-methylpyridine synthesis

Yield:1245643-68-8 52%

Reaction Conditions:

with potassium phosphate tribasic heptahydrate;C₄₅H₅₃ClFeNO₂PPd in water;toluene at 100; for 8 h;Inert atmosphere;Suzuki coupling;

Steps:

4.2. General experimental procedure

General procedure: Potassium phosphate (0.75 mmol) and IIe (1 mol %) was added to the solution of aryl halides (0.25 mmol) and cyclopropylboronic acid (0.5 mmol) in toluene (2.0 mL) and water (100 μL). The mixture was heated to 100 °C for a proper time under nitrogen atmosphere and cooled to room temperature. Water (10 mL) was added and the mixture was extracted with EtOAc (3×15 mL), evaporated and purified by chromatography on silica gel.

References:

Zhang, Min;Cui, Xiuling;Chen, Xiaopei;Wang, Lianhui;Li, Jingya;Wu, Yusheng;Hou, Lifen;Wu, Yangjie [Tetrahedron,2012,vol. 68,# 3,p. 900 - 905] Location in patent:experimental part