![](/CAS/GIF/393-53-3.gif)
3-Fluoropyridine-4-carboxylic acid synthesis
- Product Name:3-Fluoropyridine-4-carboxylic acid
- CAS Number:393-53-3
- Molecular formula:C6H4FNO2
- Molecular Weight:141.1
![Carbon dioxide](/CAS/GIF/124-38-9.gif)
124-38-9
122 suppliers
$175.00/23402
![3-Fluoropyridine-4-carboxylic acid](/CAS/GIF/393-53-3.gif)
393-53-3
195 suppliers
$10.00/1g
Yield:393-53-3 70%
Reaction Conditions:
Stage #1:3-Fluoropyridine with n-butyllithium;diisopropylamine in tetrahydrofuran at -78; for 1 h;
Stage #2:carbon dioxide in tetrahydrofuran at -78 - 20; for 1 h;
Stage #3: with hydrogenchloride in tetrahydrofuran;water; pH=5
Steps:
1
3-Fluoropyridine (25 g, 257mmol) was added to a solution of butyllithium EPO
References:
MITSUBISHI PHARMA CORPORATION;SANOFI-AVENTIS WO2006/36015, 2006, A2 Location in patent:Page/Page column 121-122
![3-Fluoropyridine](/CAS/GIF/372-47-4.gif)
372-47-4
367 suppliers
$5.00/1g
![Carbon dioxide](/CAS/GIF/124-38-9.gif)
124-38-9
122 suppliers
$175.00/23402
![3-Fluoropyridine-4-carboxylic acid](/CAS/GIF/393-53-3.gif)
393-53-3
195 suppliers
$10.00/1g
![3-Fluoropyridine](/CAS/GIF/372-47-4.gif)
372-47-4
367 suppliers
$5.00/1g
![3-Fluoropyridine-4-carboxylic acid](/CAS/GIF/393-53-3.gif)
393-53-3
195 suppliers
$10.00/1g
![3-Fluoro-4-methylpyridine](/CAS/GIF/399-88-2.gif)
399-88-2
190 suppliers
$6.00/250mg
![3-Fluoropyridine-4-carboxylic acid](/CAS/GIF/393-53-3.gif)
393-53-3
195 suppliers
$10.00/1g
![3-Amino-4-methylpyridine](/CAS/GIF/3430-27-1.gif)
3430-27-1
456 suppliers
$13.43/1gm:
![3-Fluoropyridine-4-carboxylic acid](/CAS/GIF/393-53-3.gif)
393-53-3
195 suppliers
$10.00/1g