![](/CAS/GIF/1121-78-4.gif)
3-Hydroxy-6-methylpyridine synthesis
- Product Name:3-Hydroxy-6-methylpyridine
- CAS Number:1121-78-4
- Molecular formula:C6H7NO
- Molecular Weight:109.13
![5-METHOXY-2-METHYL-PYRIDINE](/CAS/GIF/55270-47-8.gif)
55270-47-8
63 suppliers
$65.00/100mg
![3-Hydroxy-6-methylpyridine](/CAS/GIF/1121-78-4.gif)
1121-78-4
293 suppliers
$6.00/5g
Yield:1121-78-4 84%
Reaction Conditions:
with L-Selectride in tetrahydrofuran for 24 h;Reflux;Inert atmosphere;chemoselective reaction;
Steps:
Demethylation of Methoxypyridines; General Procedure:
General procedure: Toa solution of 1 (1.00 mmol) in THF (7.0 mL) was added L-selectride(1 M in THF, 3.0 mL, 3.00 mmol, 3 equiv) under an argonatmosphere. After being refluxed and monitored by TLC, thereaction mixture was quenched with MeOH and evaporated invacuo. The residue was purified by silica gel column chromatographyto give the desired compound 2.
References:
Makino, Kosho;Hasegawa, Yumi;Inoue, Takahide;Araki, Koji;Tabata, Hidetsugu;Oshitari, Tetsuta;Ito, Kiyomi;Natsugari, Hideaki;Takahashi, Hideyo [Synlett,2019,vol. 30,# 8,p. 951 - 954]
![5-Bromo-2-methylpyridine](/CAS/GIF/3430-13-5.gif)
3430-13-5
420 suppliers
$5.00/5g
![3-Hydroxy-6-methylpyridine](/CAS/GIF/1121-78-4.gif)
1121-78-4
293 suppliers
$6.00/5g
![6-Methylpyridine-3-sulfonic acid](/CAS/GIF/4808-69-9.gif)
4808-69-9
92 suppliers
$19.00/100mg
![3-Hydroxy-6-methylpyridine](/CAS/GIF/1121-78-4.gif)
1121-78-4
293 suppliers
$6.00/5g
![5-Methyl furfural](/CAS/GIF/620-02-0.gif)
620-02-0
476 suppliers
$14.14/5gm:
![3-Hydroxy-6-methylpyridine](/CAS/GIF/1121-78-4.gif)
1121-78-4
293 suppliers
$6.00/5g
![Formaldehyde](/CAS/GIF/50-00-0.gif)
50-00-0
846 suppliers
$10.00/25g
![Furfurylamine](/CAS/GIF/617-89-0.gif)
617-89-0
265 suppliers
$15.00/25mL
![3-Hydroxy-6-methylpyridine](/CAS/GIF/1121-78-4.gif)
1121-78-4
293 suppliers
$6.00/5g