3-HYDROXYMETHYL-BETA-CARBOLINE synthesis

Yield:65474-79-5 90%

Reaction Conditions:

with lithium aluminium tetrahydride;water in tetrahydrofuran at 0 - 20; for 2 h;Reagent/catalyst;Solvent;

Steps:

3 (9H-pyrido[3,4-b]indol-3-yl)methanol (16)

Add 2.26g (10.0mmol) of compound 4, 100mL of THF into a 250mL round bottom flask, add 0.57g (15.0mmol) of LiAlH4 in batches after cooling to 0°C, and warm to room temperature to stir the reaction. After the reaction, 10 mL of H2O was added to the system, and the reaction was continued for 2 hours at room temperature to quench the reaction. After filtration, washing with dichloromethane, the filtrate was concentrated and separated and purified by Flash column, 1.78 g of white solid 16, yield: 90%.

References:

CN111333639,2020,A Location in patent:Paragraph 0088-0091; 0199-0202