3-Iodophenylacetic acid synthesis
- Product Name:3-Iodophenylacetic acid
- CAS Number:1878-69-9
- Molecular formula:C8H7IO2
- Molecular Weight:262.04
130723-54-5
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$34.00/1g
1878-69-9
174 suppliers
$27.00/1g
Yield:1878-69-9 83%
Reaction Conditions:
with sodium hydroxide in water for 4 h;Heating / reflux;
Steps:
13.1
A solution of 0.2 g of (3-iodophenyl)acetonitrile in 1.0 ml of a 1.0M aqueous sodium hydroxide solution is brought to reflux for 4 hours. The solution is extracted with diethyl ether and the aqueous phase is acidified with a 1.0M hydrochloric acid solution. The solution derived from extracting with diethyl ether is washed with water, dried over sodium sulphate, filtered and then evaporated under reduced pressure to produce 0.17 g of the expected product. Yield: 83% 1H NMR (DMSO) δ (ppm): 7.65 (s, 1H), 7.5 (d, 1H), 7.3 (d, 1H), 7.1 (m, 1H), 3.6 (s, 2H)
References:
Dublanchet, Anne-Claude;Compere, Delphine;Cluzeau, Philippe;Blais, Stephane;Denis, Alexis;Ducrot, Pierre;Courte, Karine;Descamps, Sophie US2004/72871, 2004, A1 Location in patent:Page/Page column 19
201230-82-2
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49617-83-6
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$6.00/250mg
1878-69-9
174 suppliers
$27.00/1g
14338-36-4
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$15.00/1g
1878-69-9
174 suppliers
$27.00/1g
49617-83-6
171 suppliers
$6.00/250mg
1878-69-9
174 suppliers
$27.00/1g