![](/CAS/GIF/156-38-7.gif)
4-Hydroxyphenylacetic acid synthesis
- Product Name:4-Hydroxyphenylacetic acid
- CAS Number:156-38-7
- Molecular formula:C8H8O3
- Molecular Weight:152.15
4-aminophenylacetic acid and alkali solution are prepared into sodium salt, and then sulfuric acid is added. Cool to 0°C, control the temperature at 0-5°C, and add sodium nitrate solution dropwise, and the reaction is completed for 0.5h. The obtained diazonium was added dropwise to dilute sulfuric acid at 90-95°C for about 1 hour, and the reaction was continued for 1 hour. The reaction solution was decolorized and filtered, cooled and extracted with ethyl acetate, and the extract was recovered with ethyl acetate to obtain 4-Hydroxyphenylacetic acid. The yield is about 85%.
![4-Methoxyphenylacetic acid](/CAS/GIF/104-01-8.gif)
104-01-8
514 suppliers
$6.00/10g
![4-Hydroxyphenylacetic acid](/CAS/GIF/156-38-7.gif)
156-38-7
622 suppliers
$6.00/25g
Yield:156-38-7 99%
Reaction Conditions:
with boron tribromide in dichloromethane at -78 - -15; for 4 h;Inert atmosphere;
Steps:
2-(4-Hydroxyphenyl)acetic Acid (13)
2-(4-Hydroxyphenyl)acetic acid (13) was prepared according to a literature protocol.18 To a cooled (–78 °C), stirred solution of 2-(4-methoxyphenyl)acetic acid (1.0 g, 5.08 mmol, 1 equiv) in CH2Cl2 (10 mL)was added BBr3 (12 mL, 1 M in CH2Cl2) under an inert atmosphere. The reaction was then allowed to stir over 4 h whilst warming from –78 °C to –15 °C. After complete conversion of the starting material, the reaction mixture was quenched by adding H2O (15 mL) and the aqueous layer was extracted with CH2Cl2 (3 × 20 mL). The combined organic layers were washed with brine, dried over Na2SO4 and concentrated. The obtained white solid was dried in a desiccator for 1 d to give 13 (0.90 g, 99percent). Mp 137–140 °C; Rf = 0.5 (5percent MeOH/CH2Cl2).
References:
Hussain, Mulla Althafh;Khan, Faiz Ahmed;Shashi, Shashi [Synthesis,2019,vol. 51,# 24,p. 4601 - 4610]
![4-Iodophenylacetic acid](/CAS/GIF/1798-06-7.gif)
1798-06-7
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$6.00/1g
![4-Hydroxyphenylacetic acid](/CAS/GIF/156-38-7.gif)
156-38-7
622 suppliers
$6.00/25g
![4-Hydroxyphenethyl alcohol](/CAS/GIF/501-94-0.gif)
501-94-0
600 suppliers
$14.00/25g
![4-Hydroxyphenylacetic acid](/CAS/GIF/156-38-7.gif)
156-38-7
622 suppliers
$6.00/25g
![4-Hydroxybenzyl cyanide](/CAS/GIF/14191-95-8.gif)
14191-95-8
396 suppliers
$6.00/5g
![4-Hydroxyphenylacetic acid](/CAS/GIF/156-38-7.gif)
156-38-7
622 suppliers
$6.00/25g
![BENZYL 2-(4-(BENZYLOXY)PHENYL)ACETATE](/CAS/GIF/58609-13-5.gif)
58609-13-5
8 suppliers
$1320.00/500mg
![4-Hydroxyphenylacetic acid](/CAS/GIF/156-38-7.gif)
156-38-7
622 suppliers
$6.00/25g