3-isopropyloxetan-3-ol synthesis

Yield:1408291-62-2 62%

Reaction Conditions:

in diethyl ether;

Steps:

1 Step 1

Step 1
Isopropylmagnesium chloride (13.88 mL, 27.8 mmol) was added dropwise via syringe to a solution of oxetan-3-one (2, 27.8 mmol) in Diethyl ether (110 mL) at 0° C. and stirred at this temp for 1 hr before warming up to RT.
The reaction was quenched with sat.
ammonium chloride and extracted with ether.
The organic layer was washed with brine, collected, dried over MgSO₄, filtered and partially evaporated to give the crude product 3-isopropyloxetan-3-ol (2.00 g, 62% yield) as an oil. ¹H NMR (400 MHz, CHLOROFORM-d) d 4.55 (d, J=7.0 Hz, 2H), 4.50 (d, J=7.0 Hz, 2H), 2.14-2.04 (m, 1H), 0.93 (s, 3H), 0.92 (s, 3H).

References:

US2013/115190,2013,A1 Location in patent:Page/Page column