ChemicalBook CAS DataBase List 3-METHOXY-N-PHENYLBENZAMIDE

3-METHOXY-N-PHENYLBENZAMIDE synthesis

12synthesis methods

Product Name:3-METHOXY-N-PHENYLBENZAMIDE
CAS Number:6833-23-4
Molecular formula:C14H13NO2
Molecular Weight:227.26

591-50-4 Synthesis

591-50-4
472 suppliers
$10.00/1g

5813-86-5
92 suppliers
$30.00/5g

6833-23-4
18 suppliers
$403.00/250mg

Yield:6833-23-4 97%

Reaction Conditions:

with copper(I) bromide;lithium tert-butoxide in toluene; for 24 h;Inert atmosphere;UV-irradiation;Sealed tube;

Steps:

3 Example 3 Preparation of Ν-phenyl m-methoxybenzamide

M-Methoxybenzamide (CAS No. 5813-86-5) 9.07 g (60 mmol), cuprous bromide 1.72 g (12 mmol) and lithium tert-butoxide 14.40 g (180 mmol) were weighed into a 250 mL reaction flask. Toluene (200 mL) was added and stirred to dissolve. Iodobenzene 13.38 mL (120 mmol) was added. The reaction flask was sealed with a rubber stopper, and then connected to a double-row tube, and subjected to a freeze-vacuum-nitrogen-filling operation, three times. After replacing the nitrogen gas, the reaction was carried out for 24 hours under ultraviolet light irradiation. After the reaction was completed, the reaction solution is concentrated by a rotary evaporator, and then separated by column chromatography on silica gel (eluent: petroleum ether: ethyl acetate = 10:1), after purification, 13.23 g of a white solid was obtained, yield 97%.

References:

CN108863832,2018,A Location in patent:Paragraph 0023-0025