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3-METHYL-5-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: hydrazine hydrate / ethanol / 20 °C / Reflux
2: boron tribromide / dichloromethane / 3 h / -10 °C

References:

Cheng, Huimin;Wan, Junting;Lin, Meng-I;Liu, Yingxue;Lu, Xiaoyun;Liu, Jinsong;Xu, Yong;Chen, Jianxin;Tu, Zhengchao;Cheng, Yih-Shyun E.;Ding, Ke [Journal of Medicinal Chemistry,2012,vol. 55,# 5,p. 2144 - 2153]

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