2-PHENYL-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER synthesis

4synthesis methods

Product Name:2-PHENYL-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
CAS Number:51065-76-0
Molecular formula:C16H14N2O2
Molecular Weight:266.29

6295-87-0
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2216-94-6
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2-PHENYL-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER

51065-76-0
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Yield:51065-76-0 65.7%

Reaction Conditions:

with potassium carbonate at 20; for 18 h;

Steps:

38.A A: Preparation of Ethyl 2-phenylpyrazolon,5-a1pyridine-3-carboxylate:

Example 38 l-(2-phenyl-2,4,5,6-tetrahvdrocvclopenta[c]pyrazol-3-yl)-3-(2-phenylpyrazolo[L5-a]pyridin- 3-yl)urea [00673] Step A: Preparation of Ethyl 2-phenylpyrazolon,5-a1pyridine-3-carboxylate: To a solution of 1-aminopyridinium iodide (2.22 g, 10.0 mmol) in DMF (20 mL) was added K₂C0₃ (1.93 g, 14.0 mmol) and ethyl 3-phenylpropiolate (3.30 mL, 20.0 mmol). The mixture was stirred at ambient temperature for 18 hours and was poured into chilled water (100 mL). The mixture was stirred for 30 minutes and was filtered through packed Celite, rinsing with EtOAc and H₂0. The organic layer was removed and was washed with H₂0 (4x), dried over MgS0₄, filtered and concentrated. The residual dark red-orange oil was purified by silica chromatography using a 10-50% EtOAc/hexanes gradient elution to furnish the title compound as a yellow solid (1.75 g, 65.7% yield). MS (apci) m/z = 267.0 (M+H).

References:

WO2014/78408,2014,A1 Location in patent:Paragraph 00673

6295-87-0
229 suppliers
$15.00/1g