ChemicalBook CAS DataBase List 3-METHYLENECYCLOBUTANECARBOXYLIC ACID

3-METHYLENECYCLOBUTANECARBOXYLIC ACID synthesis

4synthesis methods

Product Name:3-METHYLENECYCLOBUTANECARBOXYLIC ACID
CAS Number:15760-36-8
Molecular formula:C6H8O2
Molecular Weight:112.13

15760-35-7 Synthesis

15760-35-7
136 suppliers
$10.00/1g

15760-36-8
118 suppliers
$18.00/250mg

Yield: 100%

Reaction Conditions:

with water;potassium hydroxide in ethanolReflux;

Steps:

10.1 Step 1:
Preparation of 3-methylidenecyclobutanecarboxylic acid
Step 1:
Preparation of 3-methylidenecyclobutanecarboxylic acid
To a solution of 3-methylidenecyclobutanecarbonitrile (110 g, 1.18 mol) in ethanol (500 mL) and water (500 mL) was added potassium hydroxide (264 g, 4.7 mol) and the resulting mixture was refluxed overnight.
The ethanol was removed under reduced pressure, and then the solution was cooled to below 10° C. and acidified with concentrated HCl to pH 1.
The mixture was extracted with EtOAc (two*500 mL) and the combined organic extracts were dried over anhydrous sodium sulfate and concentrated under vacuum to afford compound the title compound (132 g, 100% yield) as yellow oil.

References:

PFIZER INC.;Cheng, Hengmiao;Johnson, JR., Theodore Otto;Kath, John Charles;Liu, Kevin Kun-Chin;Lunney, Elizabeth Ann;Nagata, Asako;Nair, Sajiv Krishnan;Planken, Simon Paul;Sutton, Scott Channing US2013/79324, 2013, A1 Location in patent:Paragraph 0934; 0935

23761-23-1 Synthesis