![](/CAS/GIF/10268-12-9.gif)
(3-NITROPHENYL)ACETIC ACID METHYL ESTER synthesis
- Product Name:(3-NITROPHENYL)ACETIC ACID METHYL ESTER
- CAS Number:10268-12-9
- Molecular formula:C9H9NO4
- Molecular Weight:195.17
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
739 suppliers
$7.29/5ml-f
![3-NITROPHENYLACETIC ACID](/CAS/GIF/1877-73-2.gif)
1877-73-2
202 suppliers
$24.00/1g
![(3-NITROPHENYL)ACETIC ACID METHYL ESTER](/CAS/GIF/10268-12-9.gif)
10268-12-9
80 suppliers
$55.00/1g
Yield: 100%
Reaction Conditions:
with chloro-trimethyl-silane at 20; for 18 h;
Steps:
118
Example 118 N- (3- {1-METHYL-2- [4- (2-METHYL-5-QUINOLINYL)-1-PIPERAZINYL] ETHYL} PHENYL) acetamide (E118) Methyl (3-nitrophenyl) acetate; Trimethylsilyl chloride (5.6 mL, 2.0 equiv. ) was added to a stirred solution of (3- nitrophenyl) acetic acid (4.0 g) in methanol (60 ML). The resulting solution was stirred at room temperature for 18 hours, then concentrated at reduced pressure and partitioned between DCM and aqueous sodium hydrogencarbonate solution. The organic phase was dried over sodium sulfate, filtered and concentrated under vacuum to give the title compound as a colourless liquid (4.2 g, 100%). 1H-NMR (300 MHz, CDCI3) 8 (ppm): 8. 15 (s, 1H), 8.07 (d, 1H), 7.60 (d, 1H), 7.47 (t, 1H), 3. 85 (s, 2H), 3.80 (s, 3H).
References:
GLAXO GROUP LIMITED WO2005/14552, 2005, A1 Location in patent:Page/Page column 80
![3-NITROPHENYLACETONITRILE](/CAS/GIF/621-50-1.gif)
621-50-1
153 suppliers
$10.00/1g
![(3-NITROPHENYL)ACETIC ACID METHYL ESTER](/CAS/GIF/10268-12-9.gif)
10268-12-9
80 suppliers
$55.00/1g
![3-NITROPHENYLACETIC ACID](/CAS/GIF/1877-73-2.gif)
1877-73-2
202 suppliers
$24.00/1g
![(3-NITROPHENYL)ACETIC ACID METHYL ESTER](/CAS/GIF/10268-12-9.gif)
10268-12-9
80 suppliers
$55.00/1g
![3-NITROPHENYLACETIC ACID](/CAS/GIF/1877-73-2.gif)
1877-73-2
202 suppliers
$24.00/1g
![(TRIMETHYLSILYL)DIAZOMETHANE](/CAS/GIF/18107-18-1.gif)
18107-18-1
208 suppliers
$33.00/5g
![(3-NITROPHENYL)ACETIC ACID METHYL ESTER](/CAS/GIF/10268-12-9.gif)
10268-12-9
80 suppliers
$55.00/1g
![Methyl phenylacetate](/CAS/GIF/101-41-7.gif)
101-41-7
493 suppliers
$15.00/25mL
![Methyl p-nitrophenylacetate](/CAS/GIF/2945-08-6.gif)
2945-08-6
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inquiry
![(3-NITROPHENYL)ACETIC ACID METHYL ESTER](/CAS/GIF/10268-12-9.gif)
10268-12-9
80 suppliers
$55.00/1g
![METHYL (2-NITRO-PHENYL)-ACETATE](/CAS/GIF/30095-98-8.gif)
30095-98-8
93 suppliers
$25.00/1g