3-(oxiran-2-yl)benzonitrile synthesis

5synthesis methods

Product Name:3-(oxiran-2-yl)benzonitrile
CAS Number:13906-62-2
Molecular formula:C9H7NO
Molecular Weight:145.16

2181-42-2 Synthesis

2181-42-2
254 suppliers
$6.00/5g

13906-62-2
16 suppliers
inquiry

Yield:13906-62-2 55%

Reaction Conditions:

with potassium hydroxide in water;acetonitrile at 60; for 15 h;

Steps:

A34.a

A solution of trimethylsulfonium iodide (4.49 g, 22.0 mmol) in acetonitrile (40 ml), KOH (2.64 g, 40.0 mmol) and H₂O (0.100 ml) was added at room temperature and stirred at 60 ^°C for 15 hours. The reaction was quenched with brine, extracted with diethyl ether (100 ml x 2), washed with brine, dried (MgSO₄) and evaporated under reduced pressure. The residue was purified by column chromatography on silica (ethyl acetate/hexane, 25/75) to give 3-(oxiran-2-yl)benzonitrile (1.63 g, 55 %, colorless oil).

References:

WO2008/8398,2008,A2 Location in patent:Page/Page column 367

24964-64-5 Synthesis