![](/CAS/GIF/885280-38-6.gif)
(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER synthesis
- Product Name:(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
- CAS Number:885280-38-6
- Molecular formula:C11H19NO3
- Molecular Weight:213.27
![(3-HYDROXY-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER](/CAS/GIF/610302-03-9.gif)
610302-03-9
111 suppliers
$30.00/250mg
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885280-38-6
167 suppliers
$8.00/250mg
Yield:885280-38-6 91%
Reaction Conditions:
with Dess-Martin periodane in dichloromethane at 20; for 2 h;Cooling with ice;
Steps:
27.D tert-butyl(3-oxocyclohexyl)carbamate
D.
tert-butyl(3-Oxocyclohexyl)carbamate
To a solution of tert-butyl (3-hydroxycyclohexyl)carbamate (4.40 g, 20.46 mmol) in DCM (250 mL) was added Dess-Martin periodinane (13.0 g, 30.70 mmol) in portions under cooling in an ice bath.
The mixture was stirred at room temperature for 2 h.
The reaction was diluted with DCM and washed with aqueous sodium carbonate.
The separated organic layer was dried over anhydrous sodium sulfate and concentrated.
The crude compound was purified by silica gel column chromatography (40% ethyl acetate in petroleum ether) to afford the title compound (4.0 g, 18.78 mmol, 91% yield). MS (ESI) m/z 214.1 [M+H]+.
References:
Papa, Patrick;Cathers, Brian Edwin;CALABRESE, Andrew Antony;WHITEFIELD, Brandon Wade;BENNETT, Brydon;CASHION, Daniel;MORTENSEN, Deborah;HUANG, Dehua;TORRES, Eduardo;PARNES, Jason;SAPIENZA, John;HANSEN, Joshua;LEFTHERIS, Katerina;CORREA, Matthew;DELGADO, Maria Mercedes;RAHEJA, Neil;BAHMANYAR, Sami;HEGDE, Sayee;NORRIS, Stephen;PLANTEVIN-KRENITSKY, Veronique US2015/175557, 2015, A1 Location in patent:Paragraph 0383
![2-Cyclohexen-1-one](/CAS/GIF/930-68-7.gif)
930-68-7
255 suppliers
$9.00/1g
![tert-Butyl carbamate](/CAS/GIF/4248-19-5.gif)
4248-19-5
373 suppliers
$5.00/5g
![(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER](/CAS/GIF/885280-38-6.gif)
885280-38-6
167 suppliers
$8.00/250mg
![tert-Butyl N-cyclohexylcarbaMate](/CAS/GIF/3712-40-1.gif)
3712-40-1
13 suppliers
$265.00/2.5g
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885280-38-6
167 suppliers
$8.00/250mg
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
820 suppliers
$13.50/25G
![(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER](/CAS/GIF/885280-38-6.gif)
885280-38-6
167 suppliers
$8.00/250mg
![3-Aminocyclohexanol](/CAS/GIF/6850-39-1.gif)
6850-39-1
161 suppliers
$15.00/250mg
![(3-OXO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER](/CAS/GIF/885280-38-6.gif)
885280-38-6
167 suppliers
$8.00/250mg