![](/CAS/GIF/58885-60-2.gif)
(3-OXO-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER synthesis
- Product Name:(3-OXO-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER
- CAS Number:58885-60-2
- Molecular formula:C8H15NO3
- Molecular Weight:173.21
![3-(BOC-AMINO)-1-PROPANOL](/CAS/GIF/58885-58-8.gif)
58885-58-8
179 suppliers
$10.00/1g
![(3-OXO-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER](/CAS/GIF/58885-60-2.gif)
58885-60-2
85 suppliers
$117.00/50mg
Yield:58885-60-2 100%
Reaction Conditions:
with N-chloro-succinimide;2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;tetrabutyl-ammonium chloride;sodium hydrogencarbonate;potassium carbonate in chloroform;water for 2 h;
Steps:
A-2 A-2-Synthesis of N-BOC-3-aminopropanal (Compound 2);
A-2-Synthesis of N-BOC-3-aminopropanal (Compound 2); 18 g (103 mmol) of Compound 1, 1.62 g (10.4 mmol) of TEMPO (tetramethyl-1-piperidinyloxy, free radical), 2.9 g (10.45 mmol) of tetrabutylammonium chloride and 21 g (75.5 mmol) of N-chlorosuccinimide are suspended in 351 ml of NaHCO3/K2CO3 (0.5N/0.05N) and 351 ml of CHCl3. The reaction mixture is vigorously stirred for 2 hours. The organic phase is separated by settling, dried over MgSO4 and then concentrated on a rotary evaporator to give the expected aldehyde in the form of a light orange oil. Yield: 100% 1H NMR (CDCl3): 1.35 (s, 9H); 2.44 (d, 2H, J=6.8 Hz); 3.21 (m, 2H); 4.90 (broad s, 1H); 6.04 (dd, 1H, J=8 and 15.6 Hz); 6.74 (td, 1H, J=6.8 and 15.6 Hz); 9.39 (d, 1H, J=8 Hz).
References:
Laboratoire L. Lafon US6809096, 2004, B1 Location in patent:Page column 7
![Carbamic acid, N-(3,3-diethoxypropyl)-, 1,1-dimethylethyl ester](/CAS/20210111/GIF/153815-24-8.gif)
153815-24-8
1 suppliers
inquiry
![(3-OXO-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER](/CAS/GIF/58885-60-2.gif)
58885-60-2
85 suppliers
$117.00/50mg
![tert-butyl N-[3-[methoxy(methyl)amino]-3-oxopropyl]carbamate](/CAS/20180703/GIF/142570-56-7.gif)
142570-56-7
31 suppliers
$45.00/50mg
![(3-OXO-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER](/CAS/GIF/58885-60-2.gif)
58885-60-2
85 suppliers
$117.00/50mg
![Methyl 3-(tert-butoxycarbonylaMino)propanoate](/CAS/20150408/GIF/42116-55-2.gif)
42116-55-2
50 suppliers
$60.00/50mg
![(3-OXO-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER](/CAS/GIF/58885-60-2.gif)
58885-60-2
85 suppliers
$117.00/50mg
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
824 suppliers
$13.50/25G
![(3-OXO-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER](/CAS/GIF/58885-60-2.gif)
58885-60-2
85 suppliers
$117.00/50mg