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3-Phenylisothiazole-4-carbonitrile synthesis

8synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: Br2 / acetic acid; benzene
2: (i) aq. NaNO2, H2SO4, H3PO4, (ii) aq. H3PO2, Cu2O
3: 4-methyl-pyridine / 15 h / Heating

References:

Naito,T. et al. [Chemical and pharmaceutical bulletin,1968,vol. 16,# 1,p. 148 - 159]