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3-(piperidin-4-yl)indolin-2-one hydrochloride synthesis

2synthesis methods
-

Yield:79098-85-4 86.5%

Reaction Conditions:

with hydrogenchloride;hydrogen;palladium on activated charcoal in methanol;acetic acid at 40; under 2574.3 Torr; for 5 h;

References:

Obase, Hiroyuki;Nakamizo, Nobuhiro;Takai, Haruki;Teranishi, Masayuki;Kubo, Kazuhiro;et al. [Chemical and Pharmaceutical Bulletin,1983,vol. 31,# 9,p. 3186 - 3197]