ChemicalBook CAS DataBase List 3-(Trifluoromethoxy)fluorobenzene

3-(Trifluoromethoxy)fluorobenzene synthesis

1synthesis methods

Product Name:3-(Trifluoromethoxy)fluorobenzene
CAS Number:1077-01-6
Molecular formula:C7H4F4O
Molecular Weight:180.1

372-20-3 Synthesis

372-20-3
369 suppliers
$7.00/5g

1077-01-6
180 suppliers
$9.00/1g

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: sodium hydride / 1,4-dioxane / Inert atmosphere; Schlenk technique; Reflux
1.2: 0 °C / Inert atmosphere; Schlenk technique; Reflux
2.1: Selectfluor; silver trifluoromethanesulfonate; phosphoric acid / dichloromethane; water / 1 h / 55 °C / Inert atmosphere; Glovebox

References:

Krishanmoorthy, Sankarganesh;Schnell, Simon D.;Dang, Huong;Fu, Fang;Prakash, G.K. Surya [Journal of Fluorine Chemistry,2017,vol. 203,p. 130 - 135]

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