3-(TRIFLUOROMETHYL)BENZALDOXIME synthesis

Yield: 93.3%

Reaction Conditions:

with hydroxylamine hydrochloride;sodium acetate in ethanol at 45; for 1 h;

Steps:

9.A A. Preparation of m-trifluoromethyl benzaldehyde oxime
In a jar, m-trifluoromethylbenzaldehyde (10.0 g, 57.4 mmol), hydroxylamine hydrochloride (5.2 g, 74.7 mmol) and anhydrous sodium acetate (9.4 g, 114.9 mmol) were dissolved in ethanol (100 mL), 45 °C reaction 1h.After the reaction is completed, it is cooled to room temperature, filtered by suction, the filter cake is washed with ethanol (50 mL×3), the filtrates are combined, and the solvent is evaporated under reduced pressure.The residue was dissolved in ethyl acetate (100 mL), washed with pure water (100 mL×2), dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to obtain 10.1 g of a white solid trifluoromethylbenzaldehyde oxime. The yield was 93.3%.

References:

Guizhou University;Yue Yi;Zhou Zhixu;Zhao Chunshen CN107382892, 2017, A Location in patent:Paragraph 0096; 0097