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ChemicalBook CAS DataBase List 3-(trifluoroMethyl)pyrazin-2-aMine
213019-67-1

3-(trifluoroMethyl)pyrazin-2-aMine synthesis

3synthesis methods
870787-06-7 Synthesis
3-(trifluoroMethyl)pyrazine-2-carboxylic acid

870787-06-7
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Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: thionyl chloride / 5 h / Reflux
1.2: 1 h / 0 - 20 °C
2.1: bromine; potassium hydroxide / water / 3 h / 90 °C

References:

SYNGENTA PARTICIPATIONS AG;WAILES, Jeffrey, Steven;CARTER, Neil, Brian;CLOUGH, John, Martin;WILLIAMS, John WO2019/57723, 2019, A1

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