![](/CAS/GIF/19955-99-8.gif)
3-VINYLBENZALDEHYDE synthesis
- Product Name:3-VINYLBENZALDEHYDE
- CAS Number:19955-99-8
- Molecular formula:C9H8O
- Molecular Weight:132.16
![3-Bromobenzaldehyde](/CAS/GIF/3132-99-8.gif)
3132-99-8
481 suppliers
$5.00/10g
![Pinacol vinylboronate](/CAS/GIF/75927-49-0.gif)
75927-49-0
206 suppliers
$6.00/1g
![3-VINYLBENZALDEHYDE](/CAS/GIF/19955-99-8.gif)
19955-99-8
56 suppliers
$138.00/1g
Yield: 63.05%
Reaction Conditions:
with palladium diacetate;sodium carbonate;triphenylphosphine in water;N,N-dimethyl-formamide at 80; for 12 h;Inert atmosphere;
Steps:
132A Example 132A
3-Bromobenzaldehyde (1g, 5.40mmol), pinacolato-4,4,5,5-tetramethyl-2-vinyl-1,3,2-borate (1.2g, 8.10mmol),Pd(OAc)2 (121.24mg, 0.54mmol) and PPh3 (283.27mg, 1.08mmol) and Na2CO3 (1.14mg, 10.80mmol) were dissolvedin a mixture of water (3mL) and DMF (9mL), the mixture was reacted at 80°C under nitrogen atmosphere for 12 hours.Thin layer chromatography (petroleum ether: ethyl acetate = 2/1) indicated that the starting material was completelyreacted. The reaction mixture was concentrated under reduced pressure and the residue was purified by silica gel columnchromatography (petroleum ether/ethyl acetate = 40/1 to 30/1) to give the title compound (as a yellowish oil, 540.00mg,3.40mmol, yield 63.05%). 1H NMR (400 MHz, METHANOL-d4) 9.99-10.05 (m, 1H), 7.98 (s, 1H), 7.71-7.86 (m, 2H),7.48-7.60 (m, 1H), 6.78-6.90 (m, 1H), 5.93 (d, J=17.57 Hz, 1H), 5.38 (d, J=11.04 Hz, 1H)
References:
Harbin Zhenbao Pharmaceutical Co., Ltd.;Medshine Discovery Inc.;CHEN, Shuhui;CHEN, Zhengxia;DAI, Meibi;XIE, Cheng;LI, Peng;ZHANG, Yang;LIANG, Guibai;WANG, Qiang;LIAO, Jiangpeng;SUN, Fei;HU, Guoping;LI, Jian EP3333157, 2018, A1 Location in patent:Paragraph 0537; 0538
![3-Bromobenzaldehyde](/CAS/GIF/3132-99-8.gif)
3132-99-8
481 suppliers
$5.00/10g
![Ethylene](/CAS/GIF/74-85-1.gif)
74-85-1
93 suppliers
$79.00/11l
![3-VINYLBENZALDEHYDE](/CAS/GIF/19955-99-8.gif)
19955-99-8
56 suppliers
$138.00/1g
![3-Bromobenzaldehyde](/CAS/GIF/3132-99-8.gif)
3132-99-8
481 suppliers
$5.00/10g
![Tributyl(vinyl)tin](/CAS/GIF/7486-35-3.gif)
7486-35-3
265 suppliers
$15.00/1g
![3-VINYLBENZALDEHYDE](/CAS/GIF/19955-99-8.gif)
19955-99-8
56 suppliers
$138.00/1g
![m-Phthalaldehyde](/CAS/GIF/626-19-7.gif)
626-19-7
410 suppliers
$5.00/5g
![3-VINYLBENZALDEHYDE](/CAS/GIF/19955-99-8.gif)
19955-99-8
56 suppliers
$138.00/1g
![3-ETHYNYLBENZALDEHYDE](/CAS/GIF/77123-56-9.gif)
77123-56-9
88 suppliers
$25.00/100mg
![3-VINYLBENZALDEHYDE](/CAS/GIF/19955-99-8.gif)
19955-99-8
56 suppliers
$138.00/1g