![](/CAS/20150408/GIF/30069-31-9.gif)
N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide synthesis
- Product Name:N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide
- CAS Number:30069-31-9
- Molecular formula:C15H13F3N2O
- Molecular Weight:294.27
![BenzaMide, N-(4-Methyl-3-nitrophenyl)-3-(trifluoroMethyl)-](/CAS/20150408/GIF/221876-21-7.gif)
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Yield:30069-31-9 93%
Reaction Conditions:
with palladium on activated charcoal;hydrogen in methanol at 20; for 2 h;
Steps:
1.2 Preparation of N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide
N-(4-Methyl-3-nitrophenyl)-3-(trifluoromethyl)benzamide (10.6 g, 32.7 mmol) obtained in Step (1) was stirred in a solvent of methanol.
The reaction solution was mixed with Pd/C (1 g, 9.40 mmol), followed by stirring under hydrogen conditions for about 2 hours at room temperature.
The reaction mixture was filtered through a Celite pad under reduced pressure, and washed with methanol.
The filtrate was concentrated under reduced pressure to obtain the title compound (8.9 g, 93 %).
1H-NMR Spectrum (300 MHz, DMSO-d6): δ 8.24 (s, 2H), 7.93(s, 1H), 7.77 (d, 1H), 7.10 (s, 1H), 6.85 (d, 2H), 4.90 (s, 2H), 2.02 (s, 3H).
MS (ESI+, m/z): 295 [M+H]+
References:
EP2876107,2015,A1 Location in patent:Paragraph 0077
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![3-(Trifluoromethyl)benzoic acid](/CAS/GIF/454-92-2.gif)
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![N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide](/CAS/20150408/GIF/30069-31-9.gif)
30069-31-9
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![3-(Trifluoromethyl)benzoyl chloride](/CAS/GIF/2251-65-2.gif)
2251-65-2
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![4-Methyl-3-nitroaniline](/CAS/GIF/119-32-4.gif)
119-32-4
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![N-(3-amino-4-methylphenyl)-3-(trifluoromethyl)benzamide](/CAS/20150408/GIF/30069-31-9.gif)
30069-31-9
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![BenzaMide, N-(4-Methyl-3-nitrophenyl)-3-(trifluoroMethyl)-](/CAS/20150408/GIF/221876-21-7.gif)
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