![](/CAS/GIF/313706-15-9.gif)
(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester synthesis
- Product Name:(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester
- CAS Number:313706-15-9
- Molecular formula:C11H19NO4
- Molecular Weight:229.27
![(3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid](/CAS/GIF/140148-70-5.gif)
140148-70-5
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$8.00/100mg
![Iodomethane](/CAS/GIF/74-88-4.gif)
74-88-4
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$15.00/10g
![(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester](/CAS/GIF/313706-15-9.gif)
313706-15-9
92 suppliers
$22.00/100mg
Yield: 100%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 4 h;
Steps:
3.1.9. Compound 7
To a solution of 615 (863 mg, 4.01 mmol), K2CO3 (829 mg, 6.00 mmol) in dry DMF (8 mL) was added MeI (300 μL, 4.82 mmol). The mixture was stirred at rt for 4 h, water was added and the whole was extracted with Et2O (three times). The Et2O solution was dried over MgSO4 and evaporated, and the residue was flash-chromatographed (n-hexane/AcOEt=3:1) to give 7 (916 mg, 100%) as a colorless oil. 1H NMR (400 MHz, CDCl3): δ 3.70 (3H, s), 3.65-3.28 (4H, m), 3.10-2.98 (1H, m), 2.18-2.05 (2H, m), 1.45 (9H, s). LRMS (ESI, [M+Na]+) 252.1.
References:
Otani, Yuko;Hori, Tetsuharu;Kawahata, Masatoshi;Yamaguchi, Kentaro;Ohwada, Tomohiko [Tetrahedron,2012,vol. 68,# 23,p. 4418 - 4428] Location in patent:experimental part
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
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![(S)-1-BOC-3-Cyanopyrrolidine](/CAS/GIF/132945-78-9.gif)
132945-78-9
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$19.00/100mg
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
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![(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester](/CAS/GIF/313706-15-9.gif)
313706-15-9
92 suppliers
$22.00/100mg
![Methyl 1-Boc-3-pyrrolidinecarboxylate](/CAS/GIF/122684-33-7.gif)
122684-33-7
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$8.00/1g
![(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester](/CAS/GIF/313706-15-9.gif)
313706-15-9
92 suppliers
$22.00/100mg
![Methyl 1-Boc-3-pyrrolidinecarboxylate](/CAS/GIF/122684-33-7.gif)
122684-33-7
225 suppliers
$8.00/1g
![(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester](/CAS/GIF/313706-15-9.gif)
313706-15-9
92 suppliers
$22.00/100mg
![(R)-1-N-Boc-beta-proline](/CAS/GIF/72925-16-7.gif)
72925-16-7
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![Methyl 1-Boc-3-pyrrolidinecarboxylate](/CAS/GIF/122684-33-7.gif)
122684-33-7
225 suppliers
$8.00/1g
![(S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester](/CAS/GIF/313706-15-9.gif)
313706-15-9
92 suppliers
$22.00/100mg
![(R)-1-N-Boc-beta-proline](/CAS/GIF/72925-16-7.gif)
72925-16-7
197 suppliers
$15.00/250mg
![(3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid](/CAS/GIF/140148-70-5.gif)
140148-70-5
192 suppliers
$8.00/100mg