1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOLE-6-SULFONYL CHLORIDE synthesis

7synthesis methods

Product Name:1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOLE-6-SULFONYL CHLORIDE
CAS Number:32103-15-4
Molecular formula:C13H10ClNO3S
Molecular Weight:295.74

1830-56-4
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1-ETHYL-2-OXO-1,2-DIHYDROBENZO[CD]INDOLE-6-SULFONYL CHLORIDE

32103-15-4
8 suppliers
$393.00/1g

Yield:32103-15-4 59%

Reaction Conditions:

with chlorosulfonic acid in chloroform at 0 - 50; for 6 h;

Steps:

4.3.4. 1-Ethyl-2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonylchloride (5)

To a solution of compound 4 (6.46 g, 33 mol) in chloroform (100 mL) was added chlorosulfonic (11.5 g, 99 mmol) dropwise at 0 °C for 10 min. The reaction mixture was heated at 50 °C for 6 h. The mixture was then poured into ice water. The reaction mixture was extracted with DCM (150 mL × 2). The organic layer was washed with brine and dried over Na₂SO₄. The solid was filtered off, and the filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel chromatography with petroleum ether/ethyl acetate (5/1, v/v) to yield the title product as a yellow solid (5.75 g, 59 %). MS (ESI), m/z for C₁₃H₁₀ClNO₃S ([M+H]⁺): Calcd 295.01, found 296.0.

References:

Zhang, Yan;Xue, Xiaoqian;Jin, Xiangyu;Song, Yu;Li, Jing;Luo, Xiaoyu;Song, Ming;Yan, Weiqun;Song, Hongrui;Xu, Yong [European Journal of Medicinal Chemistry,2014,vol. 78,p. 431 - 441]

130-00-7 Synthesis

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32103-15-4
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32103-15-4
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32103-15-4
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