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(1-BENZYL-3,5-DIMETHYL-1H-PYRAZOL-4-YL)-ACETIC ACID synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / 0 °C
1.2: 20 °C
2.1: acetic acid / 20 °C
3.1: trifluoroacetic acid / chloroform / 20 °C

References:

Andrés, Miriam;Bravo, Mónica;Buil, Maria Antonia;Calbet, Marta;Castro, Jordi;Domènech, Teresa;Eichhorn, Peter;Ferrer, Manel;Gómez, Elena;Lehner, Martin D.;Moreno, Imma;Roberts, Richard S.;Sevilla, Sara [Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,# 11,p. 3349 - 3353]

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