tert-Butyl 8-benzyl-2,8-diazaspiro[4.5]decane-2-carboxylate synthesis

8synthesis methods

Product Name:tert-Butyl 8-benzyl-2,8-diazaspiro[4.5]decane-2-carboxylate
CAS Number:336191-16-3
Molecular formula:C20H30N2O2
Molecular Weight:330.46

24424-99-5 Synthesis

24424-99-5
825 suppliers
$13.50/25G

336191-15-2
71 suppliers
$58.00/100mg

tert-Butyl 8-benzyl-2,8-diazaspiro[4.5]decane-2-carboxylate

336191-16-3
26 suppliers
$678.72/1g

Yield:336191-16-3 1.4 gm (29%)

Reaction Conditions:

with dmap;N-ethyl-N,N-diisopropylamine in dichloromethane;

Steps:

19.F Step F

Step F Preparation of tert-butyl 8-benzyl-2,8-diazaspiro[4.5]decane-2-carboxylate The product from Step E was dissolved in 30 ml of CH₂Cl₂. To this solution was added DIEA (5.4 ml, 31.4 mmol), DMAP (12.1 mg, 0.1 mmol), and di-tert-butyl dicarbonate (2.5 gm, 11.5 mmol). The reaction mixture was stirred overnight at room temperature. The solvent was evaporated and the residue purified by RP-HPLC yielding 1.4 gm (29%) of the product. MS (ES) 331 (M+H)⁺

References:

US2003/55244,2003,A1

2-Oxa-8-azaspiro[4.5]decane-1,3-dione, 8-(phenylMethyl)-

34702-66-4
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336191-16-3
26 suppliers
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References

3612-20-2 Synthesis

3612-20-2
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336191-16-3
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$678.72/1g

References

ETHYL 2-(1-BENZYL-4-PIPERIDINYLIDENE)-2-CYANOACETATE

1463-52-1
35 suppliers
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336191-16-3
26 suppliers
$678.72/1g

References

1-BENZYL-4-CARBOXYMETHYL-PIPERIDINE-4-CARBOXYLIC ACID

40117-92-8
16 suppliers
$439.00/1g

336191-16-3
26 suppliers
$678.72/1g

References