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ChemicalBook CAS DataBase List 5-((1H-pyrrol-2-yl)methyl)-1H-pyrrole-2-carbaldehyde

5-((1H-pyrrol-2-yl)methyl)-1H-pyrrole-2-carbaldehyde synthesis

4synthesis methods
-

Yield:36746-27-7 32%

Reaction Conditions:

Stage #1: di(pyrrol-2-yl)methanewith 2-mesitylmagnesium bromide in tetrahydrofuran at 20; for 0.166667 h;
Stage #2: phenyl formate in tetrahydrofuran at -78 - 20; for 2 h;
Stage #3: with sodium hydroxide in water;acetonitrile at 20; for 1 h;

References:

Ptaszek, Marcin;McDowell, Brian E.;Lindsey, Jonathan S. [Journal of Organic Chemistry,2006,vol. 71,# 11,p. 4328 - 4331]