ChemicalBook CAS DataBase List Benzoic acid, 2-amino-4,6-difluoro-, methyl ester (9CI)

Benzoic acid, 2-amino-4,6-difluoro-, methyl ester (9CI) synthesis

6synthesis methods

Product Name:Benzoic acid, 2-amino-4,6-difluoro-, methyl ester (9CI)
CAS Number:379228-57-6
Molecular formula:C8H7F2NO2
Molecular Weight:187.14

126674-77-9
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$21.00/250mg

74-88-4
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Benzoic acid, 2-amino-4,6-difluoro-, methyl ester (9CI)

379228-57-6
57 suppliers
$44.00/250mg

Yield:379228-57-6 88%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 20; for 2 h;Inert atmosphere;

Steps:

1.2 Step 2: Methyl 2-amino-4, 6-difluoro-benzoate

To a suspension of 2-amino-4,6-difluoro-benzoic acid (94.0 g, 543.0 mmol) and K2CO3 (112.6 g, 814.5 mmol) in DMF (1L) was added iodomethane (92.5 g, 651.6 mmol) dropwise under N2 atmosphere, and the mixture was stirred at 20 °C for 2 h. The mixture was quenched with water (3.5 L), and stirred at 20 °C for 30 min. The suspension was filtered. The cake was washed with 1 L of a solution of a 20: 1 petroleum ether: EtO Ac and dried under vacuum to afford the title compound (89 g, 88%) as brown solid. LCMS: [M+H]⁺ 188.1.

References:

WO2020/257416,2020,A1 Location in patent:Page/Page column 69

126674-77-9
123 suppliers
$21.00/250mg