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5-(TRIFLUOROMETHYL)-3-(4-METHOXYPHENYL)-1H-PYRAZOLE synthesis

11synthesis methods
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Yield:380905-15-7 93%

Reaction Conditions:

with 1,8-diazabicyclo[5.4.0]undec-7-ene;toluene-4-sulfonic acid hydrazide in toluene at 60; for 6 h;regioselective reaction;

References:

Zhu, Chuanle;Zeng, Hao;Liu, Chi;Cai, Yingying;Fang, Xiaojie;Jiang, Huanfeng [Organic Letters,2020,vol. 22,# 3,p. 809 - 813] Location in patent:supporting information