![](/CAS/GIF/39137-13-8.gif)
2-(4-Oxo-2-thioxo-3-thiazolidinyl)propionic acid, 95% synthesis
- Product Name:2-(4-Oxo-2-thioxo-3-thiazolidinyl)propionic acid, 95%
- CAS Number:39137-13-8
- Molecular formula:C6H7NO3S2
- Molecular Weight:205.2547
![Carbon disulfide](/CAS/GIF/75-15-0.gif)
75-15-0
236 suppliers
$40.00/100g
![Sodium chloroacetate](/CAS/GIF/3926-62-3.gif)
3926-62-3
261 suppliers
$21.69/250g
![DL-Alanine](/CAS/GIF/302-72-7.gif)
302-72-7
617 suppliers
$8.00/100g
![2-(4-Oxo-2-thioxo-3-thiazolidinyl)propionic acid, 95%](/CAS/GIF/39137-13-8.gif)
39137-13-8
9 suppliers
$200.00/500mg
Yield:39137-13-8 81.2%
Reaction Conditions:
Stage #1: carbon disulfide;rac-Ala-OHwith sodium hydroxide in water at 100; for 0.0833333 h;Microwave irradiation;
Stage #2: sodium monochloroacetic acid in water at 40 - 100; for 0.0833333 h;Microwave irradiation;Solvent;
Steps:
General procedure for the microwave-assisted synthesisof N-substituted rhodanines (2a-g)
General procedure: Mixture of amine or amino acid (1 mol), sodium hydroxide (22 %) and carbon disulfide (1 mol) in 3 ml water was reacted in a microwave reactor (CEM Discover, Benchmate,USA) for 5 min at 100 °C at 80 W. After automatedcooling to 40 °C, sodium chloroacetate (1 mol) was addedand the mixture was reacted again at 100 °C for 5 min.After cooling (40 °C), conc. HCl (3 ml) was added and thereaction was completed at 110 C for 20-30 min. Thecrude product was extracted with ethyl acetate and purified(Nitsche and Klein, 2012).
References:
Ali Muhammad, Sulaiman;Ravi, Subban;Thangamani, Arumugam [Medicinal Chemistry Research,2016,vol. 25,# 5,p. 994 - 1004]