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ChemicalBook CAS DataBase List (3R,4S)-rel-1-Boc--3,4-diaMinopyrrolidine

(3R,4S)-rel-1-Boc--3,4-diaMinopyrrolidine synthesis

7synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 5 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C
1.2: 0 - 65 °C
2.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide; water / tetrahydrofuran / 20 °C
3.1: triethylamine / dichloromethane / 20 °C
4.1: sodium azide / N,N-dimethyl-formamide / 24 h / 90 °C
5.1: 10 wt% Pd(OH)2 on carbon; hydrogen / methanol / 4 h / 20 °C

References:

Cho, Hyunwook;Hah, Jung-Mi;Im, Daseul;Jang, Miyoung;Moon, Hyungwoo;Oh, Youri;Yang, Songyi [International Journal of Molecular Sciences,2020,vol. 21,# 5]

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