ChemicalBook CAS DataBase List (4-(1,1-difluoroethyl)phenyl)methanol

(4-(1,1-difluoroethyl)phenyl)methanol synthesis

5synthesis methods

Product Name:(4-(1,1-difluoroethyl)phenyl)methanol
CAS Number:55805-25-9
Molecular formula:C9H10F2O
Molecular Weight:172.17

444915-84-8 Synthesis

444915-84-8
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55805-25-9
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Yield:55805-25-9 99%

Reaction Conditions:

with lithium aluminium tetrahydride in tetrahydrofuran at 100; for 2 h;

Steps:

1.2 Step two: 4- (1,1-difluoroethyl) benzyl alcoholPreparation

LAH (lithium aluminum hydride) (1.00 g, 26.4 mmol, 3 eq) was dissolved in 50 mL THF,60 oil bath for 3h,Then the reaction system was cooled to below 0 ,A solution of methyl 4- (1,1-difluoroethyl) benzoate (1.76 g, 8.8 mmol) in 8 mL THF was slowly added dropwise to the reaction flask,After the addition was completed, the mixture was brought to 100 ° C and refluxed for 2h.Stop heatingThe reaction system was cooled to below 0 ,The reaction was quenched by adding saturated NaH2PO4 solution,EA extraction,The combined organic phase,Dried over anhydrous Na2SO4,filter,Concentrated to give 1.50 g of 4- (1,1-difluoroethyl) benzyl alcohol as a yellow liquid,Yield 99%.

References:

CN107311846,2017,A Location in patent:Paragraph 0023; 0026; 0027