ChemicalBook CAS DataBase List 4-(1H-1,2,4-Triazol-1-ylmethyl)aniline

4-(1H-1,2,4-Triazol-1-ylmethyl)aniline synthesis

4synthesis methods

Product Name:4-(1H-1,2,4-Triazol-1-ylmethyl)aniline
CAS Number:119192-10-8
Molecular formula:C9H10N4
Molecular Weight:174.2

119192-09-5 Synthesis

119192-09-5
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$80.00/1g

119192-10-8
253 suppliers
$10.00/1g

Yield:119192-10-8 100%

Reaction Conditions:

with hydrogenchloride;palladium-carbon in ethanol;water;ethyl acetate;

Steps:

1.2 2.

2. 1-(4-Aminophenyl)methyl-1,2,4-triazole. Hydrochloride A solution of 1-(4-nitrophenyl)methyl-1,2,4-triazole (10.0 g, 49 mmol) in ethanol (50 ml), ethyl acetate (50 ml), 5N HCl (10 ml) and water (10 ml) was hydrogenated over 10% Pd/C(1.0 g) at 40 psi, in a Parr apparatus, until an uptake of 188 psi, had been observed (approx 10 mins). The catalyst was removed by filtration through hyflo and the solvent removed under vacuum. The residue was azeotroped with ethanol (*2) to give the title-amine hydrochloride (10.6 g, 100%). δ (360 MHz, D₂ O) 5.53 (2H, s, CH₂), 7.37-7.48 (4H, m, Ar--H), 8.12 (1H, s, Ar--H), 8.66 (1H, s, Ar--H).

References:

US5567726,1996,A