4-(3,4-DIFLUOROPHENYL)-4-PIPERIDINOL synthesis

5synthesis methods

Product Name:4-(3,4-DIFLUOROPHENYL)-4-PIPERIDINOL
CAS Number:233261-74-0
Molecular formula:C11H13F2NO
Molecular Weight:213.22

871112-36-6 Synthesis

1-BOC-4-(3,4-DIFLUOROPHENYL)-4-HYDROXYPIPERIDINE

871112-36-6
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233261-74-0
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Yield:233261-74-0 100%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20; for 1 h;

Steps:

2.2

Preparation of 4-(3,4-difluorophenyl)piperidin-4-ol (111). To amagnetically stirred solution of tert-butyl 4-(3,4-difluorophenyl)-4- hydroxypiperidine-1 -carboxylate (110, 212 mg, 0.677 mmol) in dichloromethane (5 mL), was added trifluoroacetic acid (1 mL) and reaction mixture was left to stir at room temperature for 1 h. This was then concentrated under vacuum to provide 111 (144 mg, 100%). This material was carried forward without further purification.

References:

WO2011/103126,2011,A1 Location in patent:Page/Page column 39