4-(3-Aminopropoxy)benzonitrile synthesis

3synthesis methods

Product Name:4-(3-Aminopropoxy)benzonitrile
CAS Number:116753-55-0
Molecular formula:C10H12N2O
Molecular Weight:176.22

4-[3-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PROPOXY]BENZENECARBONITRILE

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Yield:116753-55-0 41%

Reaction Conditions:

Stage #1: 4-[3-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]benzonitrilewith hydrazine in methanol;water; for 1 h;Heating / reflux;
Stage #2: with hydrogenchloride;water for 1.5 h;

Steps:

18.c (c) 4-(3-Aminopropoxy)benzonitrile

[0395] A mixture of 4-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]-benzonitrile (25.5 g, 83 mmol, from step (b) above) and hydrazine hydrate (4.15 g, 83 mmol) in methanol (100 mL) was refluxed for 1 h before water (120 mL) was added. The methanol was evaporated under reduced pressure and concentrated hydrochloric acid (120 mL) was added. The resulting mixture was heated on a steam bath for 1.5 h and then cooled in the refrigerator overnight. The resulting precipitate was filtered off and the filtrate was concentrated in vacuo. Water was added to the resulting residue and the solution made basic. The aqueous solution was extracted with DCM, which organic layer was then separated, dried and concentrated in vacuo to yield 6 g (41%) of the sub-title compound.

References:

US2004/229900,2004,A1 Location in patent:Page 21

767-00-0 Synthesis

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References

1197-19-9 Synthesis

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References