4-(3-BROMO-PROPOXY)-PHENOL synthesis
- Product Name:4-(3-BROMO-PROPOXY)-PHENOL
- CAS Number:68065-11-2
- Molecular formula:C9H11BrO2
- Molecular Weight:231.09
80199-92-4
19 suppliers
$137.00/1g
68065-11-2
20 suppliers
$764.02/250MG
Yield:68065-11-2 98%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in tetrahydrofuran; under 2068.65 Torr;
Steps:
4
[3-(4-Benzyloxy-phenoxy)-propyl]-bromide (10 g, 31.1 mmol) was dissolved in THF (100 mL). To this solution was added 10% palladium on carbon (1 g) as a suspension in THF (20 mL). The resulting suspension was placed on a Parr hydrogenator at 40 psi of H2, and shaken overnight. The reaction mixture was filtered through a pad of diatomaceous earth, and the filtrate was concentrated under reduced pressure to give 7 g (30.5 mmol, 98% yield) of a tan solid. 1H NMR: (400 MHz, CDCl3) 6.76 (d, J=9.1, 2H), 6.69 (d, 9.1, 2H), 4.00 (t, J=5.9, 2H), 3.60 (t, J=6.6, 2H), 2.23 (m, J=6.1, 2H).
References:
US2008/194630,2008,A1 Location in patent:Page/Page column 28
123-31-9
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$13.00/25g
109-64-8
498 suppliers
$10.00/5g
68065-11-2
20 suppliers
$764.02/250MG
103-16-2
524 suppliers
$5.00/1g
68065-11-2
20 suppliers
$764.02/250MG
123-31-9
825 suppliers
$13.00/25g
68065-11-2
20 suppliers
$764.02/250MG
108534-47-0
70 suppliers
$35.79/250mg
68065-11-2
20 suppliers
$764.02/250MG