4-(3-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE synthesis
- Product Name:4-(3-CHLOROPHENOXY)PIPERIDINE HYDROCHLORIDE
- CAS Number:63843-53-8
- Molecular formula:C11H15Cl2NO
- Molecular Weight:248.15
5382-16-1
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$9.00/5G
352-33-0
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$9.00/1g
63843-53-8
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$64.00/100mg
Yield:63843-53-8 83.2%
Reaction Conditions:
Stage #1: 4-HYDROXYPIPERIDINEwith potassium tert-butylate in 1-methyl-pyrrolidin-2-one at 65; for 0.5 h;Inert atmosphere;Large scale;
Stage #2: 1-Chloro-4-fluorobenzene in 1-methyl-pyrrolidin-2-one at 65 - 75; for 4 h;Inert atmosphere;Large scale;
References:
Frutos, Rogelio P.;Tampone, Thomas G.;Mulder, Jason A.;Rodriguez, Sonia;Yee, Nathan K.;Yang, Bing-Shiou;Senanayake, Chris H. [Organic Process Research and Development,2016,vol. 20,# 5,p. 982 - 988]
333954-83-9
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63843-53-8
43 suppliers
$64.00/100mg
106-48-9
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$10.00/5G
109384-19-2
474 suppliers
$5.00/1g
63843-53-8
43 suppliers
$64.00/100mg