4-(3,4-DICHLOROPHENOXY)PIPERIDINE synthesis

4synthesis methods

Product Name:4-(3,4-DICHLOROPHENOXY)PIPERIDINE
CAS Number:245057-73-2
Molecular formula:C11H13Cl2NO
Molecular Weight:246.13

1-Piperidinecarboxylic acid, 4-(3,4-dichlorophenoxy)-, 1,1-dimethylethyl ester

260441-48-3
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245057-73-2
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Yield:245057-73-2 87%

Reaction Conditions:

with hydrogenchloride in ethyl acetate at 25; for 2 h;

Steps:

33.2 Step 2: 4-(3,4-dichlorophenoxy)piperidine.

To a solution of tert-butyl 4-(3,4-dichlorophenoxy)piperidine-1-carboxylate (1.3 g, 3.75 mmol) in EtOAc (10 ml_) was added HCI/EtOAc (4 M, 10 ml_). The mixture was stirred at 25 °C for 2h, filtered and the solids were dried over in vacuo to afford 4-(3,4-dichlorophenoxy)piperidine (0.8 g, 3.25 mmol, 87%) as a white solid.

References:

WO2021/247916,2021,A1 Location in patent:Page/Page column 82; 83