![](/CAS/GIF/97839-99-1.gif)
4-(4-CHLORO-PHENOXY)-PIPERIDINE synthesis
- Product Name:4-(4-CHLORO-PHENOXY)-PIPERIDINE
- CAS Number:97839-99-1
- Molecular formula:C11H14ClNO
- Molecular Weight:211.69
![tert-butyl 4-(4-chlorophenoxy)piperidine-1-carboxylate](/CAS/GIF/333954-83-9.gif)
333954-83-9
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![4-(4-CHLORO-PHENOXY)-PIPERIDINE](/CAS/GIF/97839-99-1.gif)
97839-99-1
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$60.00/100mg
Yield:97839-99-1 99%
Reaction Conditions:
Stage #1: tert-butyl 4-(4-chlorophenoxy)piperidine-1-carboxylatewith trifluoroacetic acid in dichloromethane; for 5 h;
Stage #2: with sodium hydroxide in water at 5 - 10;
Steps:
64
Preparation of 4-(4-chloro-phenoxy)-piperidine To a solution of triphenyl phosphine (1.3 g, 4.96 mmol) in THF was added DIAD (753 mg, 3.72 mmol) at 0° C. and the mixture was stirred for 1 hour. A solution of 4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester (500 mg, 2.48 mmol) and 4-chlorophenol (320 mg, 2.48 mmol) in THF was then added at 0° C. and the mixture was stirred at room temperature overnight. The mixture was then concentrated and purified through Si-gel column (2% ethyl acetate-hexane) to afford 450 mg (58%) of 4-(4-Chloro-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester. To a solution of 4-(4-Chloro-phenoxy)-piperidine-1-carboxylic acid tert-butyl ester (450 mg, 1.45 mmol)) in DCM was added trifluoroacetic acid (1.1 ml, 14.5 mmol) and the solution was stirred for about 5 hours. The reaction mass was then concentrated and washed with dry ether. The TFA salt was diluted with a minimum volume of water and neutralized with aq. NaOH solution at 5-10° C. Extraction of the neutralized solution followed by concentration afforded 300 mg (99%) of 4-(4-Chloro-phenoxy)-piperidine. LC/MS [M+H]+: 212.3
References:
US2010/168080,2010,A1 Location in patent:Page/Page column 57-58
![4-chloropyridine](/CAS/GIF/626-61-9.gif)
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![Pyridine, 4-(4-chlorophenoxy)-](/CAS/20210305/GIF/28231-84-7.gif)
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97839-99-1
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$60.00/100mg
![4-Chlorophenol](/CAS/GIF/106-48-9.gif)
106-48-9
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![4-(4-CHLORO-PHENOXY)-PIPERIDINE](/CAS/GIF/97839-99-1.gif)
97839-99-1
52 suppliers
$60.00/100mg