4-(3-QUINOLINYL)BENZONITRILE synthesis
- Product Name:4-(3-QUINOLINYL)BENZONITRILE
- CAS Number:57479-26-2
- Molecular formula:C16H10N2
- Molecular Weight:230.26
Yield:57479-26-2 329 mg
Reaction Conditions:
Stage #1: 4-bromobenzenecarbonitrilewith isopropylmagnesium chloride in tetrahydrofuran at 0; for 2 h;Inert atmosphere;
Stage #2: with Zn(OPiv)2*2LiCl in tetrahydrofuran at 0; for 0.5 h;Inert atmosphere;
Stage #3: 3-bromoquinolinewith [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride in tetrahydrofuran at 25; for 2 h;Inert atmosphere;Negishi coupling reaction;
References:
Bernhardt, Sebastian;Manolikakes, Georg;Kunz, Thomas;Knochel, Paul [Angewandte Chemie - International Edition,2011,vol. 50,# 39,p. 9205 - 9209] Location in patent:supporting information; experimental part
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