4-(4-CHLORO-3-NITRO-BENZENESULFONYL)-MORPHOLINE synthesis

Yield:22179-31-3 24 g

Reaction Conditions:

with triethylamine in dichloromethane at -40; for 1 h;

Steps:

Intermediate 95:
4-[(4-chloro-3-nitrophenyl)sulfonyl]morpholine

At -40°C, to22g 4-chloro-3-nitrobenzenesulfonyl chloride (CAS97-08-5) in 330ml dichloromethane was added dropwise 18ml of triethylamine and 7.49g morpholine (CAS110-91-8) and stirred at -40°C for 1 hour, the temperature was slowly raised to room temperature. Was washed with water and saturated sodium chloride solution, the reaction mixture, with magnesium sulfate and completely concentrated under vacuum. To give 24g of the title compound as a yellow solid.

References:

CN105518001,2016,A Location in patent:Paragraph 0433