ChemicalBook CAS DataBase List 4-(4-Cyanophenoxy)benzoic acid

4-(4-Cyanophenoxy)benzoic acid synthesis

9synthesis methods

Product Name:4-(4-Cyanophenoxy)benzoic acid
CAS Number:50793-29-8
Molecular formula:C14H9NO3
Molecular Weight:239.23

90178-71-5 Synthesis

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Yield:50793-29-8 70%

Reaction Conditions:

with Jones reagent in acetone;Cooling with ice;

Steps:

77.2

Step 2: 4-(4-Cyano-phenoxy)-benzoic acid; To an ice cold solution of 4-(4-cyano-phenoxy)-benzaldehyde (2.0 g, 8.9 mmol) in acetone (10 ml_), the Jone's reagent (7 ml.) was added slowly drop wise until reaction completes. Acetone was removed completely and diluted with water. The mixture was extracted with ethyl acetate, the combined organic layers were dried over anhydrous sodium sulphate and concentrated to get the title compound (1.5 g, 70%)1 H NMR (300 MHz, DMSO-d6): δ (ppm) = 7.2(m, 4H), 7.8(d, 2H), 8.0(d, 2H).

References:

WO2010/115736,2010,A2 Location in patent:Page/Page column 127

99-96-7 Synthesis