![](/CAS/GIF/85112-35-2.gif)
4-(4-ETHYL-PHENYL)-THIAZOL-2-YLAMINE synthesis
- Product Name:4-(4-ETHYL-PHENYL)-THIAZOL-2-YLAMINE
- CAS Number:85112-35-2
- Molecular formula:C11H12N2S
- Molecular Weight:204.29
Yield:85112-35-2 80%
Reaction Conditions:
with iodine at 100; for 8 h;
Steps:
General procedure for synthesis of 2-amino-4-(substituted-phenyl)-1,3-thiazoles
General procedure: A mixture of thiourea (7, 50 mmol), the corresponding acetophenone (6, 25 mmol) and iodine(25 mmol) is stirred at 100 °C for 8 h. Then the reaction mixture is cooled, extracted with diethylether to remove excess of acetophenone, and then washed with aqueous sodium thiosulfate to remove excess iodine and later with cold water. The crude product is dissolved in hot water, filtered to remove sulphone, and the filtrate is basified with aqueous Na2CO3 to yield the corresponding 2-amino-4-(substituted-phenyl)-1,3-thiazole (5). The crude product is purified by recrystallization from alcohol. The synthesis and spectral data of compounds 5a-i have been reported by us earlier [2]. The data in respect of compounds 5j-l is described here.
References:
Koppireddi, Satish;Chilaka, Deepika Raj Kumari;Avula, Sreenivas;Komsani, Jayaram Reddy;Kotamraju, Srigiridhar;Yadla, Rambabu [Bioorganic and Medicinal Chemistry Letters,2014,vol. 24,# 23,p. 5428 - 5431] Location in patent:supporting information
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85112-35-2
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