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4-(4-IODO-PHENYL)-4-OXO-BUTYRIC ACID synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: aluminum (III) chloride / 1,2-dichloro-ethane
2.1: hydrogenchloride / water / Heating
3.1: hydrogenchloride; sodium nitrite / water / 0 °C
3.2: 20 °C

References:

Masurier, Nicolas;Lebrun, Aurélien;Canitrot, Damien;Chezal, Jean-Michel;Moreau, Emmanuel [Tetrahedron Letters,2016,vol. 57,# 24,p. 2583 - 2586]

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