[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]acetonitrile synthesis

1synthesis methods

Product Name:[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]acetonitrile
CAS Number:301235-86-9
Molecular formula:C12H10N2OS
Molecular Weight:230.29

7357-70-2
169 suppliers
$15.00/1g

2632-13-5
356 suppliers
$5.00/25mg

[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]acetonitrile

301235-86-9
21 suppliers
inquiry

Yield:301235-86-9 75%

Reaction Conditions:

in ethanol; for 3 h;Reflux;

Steps:

13 EXAMPLE 13 2-(4-(4-Methoxyphenyl)thiazol-2-yl)acetonitrile

This compound was synthesized from 2-bromo-1-(4-methoxyphenyl)ethanone and 2-cyanothioacetamide as described in example 1 step 1 (1.5 g, yield 75%). ¹H NMR (300MHz, CDCl₃) δ 7.83 (d, J = 8.9 Hz, 2H), 7.35 (s, 1 H), 6.98 (d, J = 8.9 Hz, 2H), 4.17 (s, 2H), 3.86 (s, 3H). MS (ESI) m/z: Calculated for C₁₂H₁₀N₂OS: 230.05; found: 231.2 (M+H)⁺.

References:

EP2533783,2015,B1 Location in patent:Paragraph 0129-0130; 0191-0192